April 2026 opened with a statement. A single $10B round to Project Prometheus – Jeff Bezos’s AI company targeting the physical economy – set the tone for a month. Leveraging data from CrunchBase, this report tracks the largest US startup funding rounds of April 2026, covering each company’s round type, founding team, industry focus, investor syndicate, and total equity raised to date. Beyond the headline numbers, the deals reflect a decisive shift in venture conviction: defense tech, nuclear energy, autonomous systems, and AI infrastructure are no longer emerging themes – they’re where the biggest checks are going. READ MORE